Objective To investigate the expression of CD44,and SOX2 in colorectal cancer tissues and its relationship with prognosis.Methods 60 colorectal cancer patients admitted to our hospital from January 2018 to June 2021 and 50 colorectal adenoma patients surgically treated during the same period were selected,and specimens of cancer/tumour tissues and normal mucosal tissues adjacent to the cancer/tumour were collected,and the expression of CD44 and SOX2 was detected by immunohistochemistry in the different tissue specimens.With a follow-up period of 2 years,the factors influencing the prognosis of colorectal cancer were analysed by Cox regression.The disease progression-free survival rates of patients with different CD44 and SOX2 expression levels were compared.Results The positive expression rate of CD44 and SOX2 in colorectal cancer tissues was higher than that in colorectal adenoma tissues and normal tissues adjacent to the cancer(P＜0.05).Cox regression analysis showed that age,TMN stage,differentiation,lymph node metastasis,and the expression of CD44 and SOX2 were the main influencing factors on the prognosis of colorectal cancer(P＜0.05).The 2-year progression-free survival rate of CD44 and SOX2 double-positive patients was lower than that of single-positive and negative patients(P＜0.05).Conclusions CD44 and SOX2 are abnormally expressed in colorectal cancer tissues,which may be involved in the progression of colorectal cancer,or may become a potential cancer stem cells(CSC)marker for colorectal cancer.
万方数据
维普
