Objective To compare the blood drug concentration,efficacy,and safety of domestic and imported Levetiracetam(LEV)in epilepsy patients.Methods Collect blood samples from 96 epilepsy patients taking domestic or imported LEV drugs,including 62 domestic cases and 34 imported cases,and use high-performance liquid chromatography to detect the blood drug concentration of patients.Observe the efficacy and adverse reactions of two drugs based on the number of epileptic seizures before and after medication.Results The domestic LEV blood concentration value was 9.32(6.57)μg/mL,and the imported LEV blood concentration value is 9.5(6.68)μg/mL.56 cases of domestically produced LEV showed improvement in symptoms,with a total clinical effective rate of 90.3％.30 cases showed improvement in imported LEV symptoms,with a total clinical effective rate of 88.2％.The incidence of adverse reactions for the two was 14.5％and 14.7％,respectively,there was no statistically significant difference.Conclusion There is no difference in metabolism,therapeutic efficacy,and safety between domestic and imported LEV in epilepsy patients,providing reference for the clinical application of domestic LEV.
万方数据
维普
