Objective To explore the changes of respiratory pathogenic spectrum of children with fever and respiratory syndrome in the post epidemic era of COVID-19.Methods Children with fever and respiratory symptoms admitted to Hangzhou Children's Hospital and Hangzhou First People's Hospital affiliated to Zhejiang University from December 2020 to April 2022 were included in the study.They underwent throat swab SARS-CoV-2 nucleic acid testing screening and 13 respiratory pathogen nucleic acid testing.Clinical characteristics were analyzed.Results All enrolled children had negative throat swab SARS-CoV-2 nucleic acid test results.The positive detection rate of 13 respiratory pathogens in throat swabs was 69.64％,including 22 cases of mixed infection,accounting for 7.86％.The top five pathogens detected were:rhinovirus 16.43％,respiratory syncytial virus 14.29％,parainfluenza virus 13.21％,parainfluenza virus 12.14％,and influenza B virus 6.07％.Among them,there were 12 family cluster cases,and 17 of the 24 adults in close contact were positive for respiratory pathogens(70.83％).Most of them had no obvious fever or respiratory symptoms,or only mild upper respiratory symptoms.The pathogens were mainly rhinovirus,respiratory syncytial virus,and influenza B virus.All rhinoviruses were CA type(53/53),respiratory syncytial viruses were BA type(42/42),influenza B viruses were Victoria series(23/23),adenoviruses were group B in 3 cases and group C in 6 cases.Conclusion The prevention and control measures of novel coronavirus pneumonia curb the social mass transmission of common respiratory pathogens in children.The mode of onset has shifted to sporadic and family cluster transmission as the main characteristics.
万方数据
维普
