Objective To investigate the value of preoperative serum thyroglobulin(TG)/thyroid-stimulating hormone(TSH)levels in predicting the risk of recurrence after radical thyroid cancer surgery.Methods The clinical data of 110 thyroid cancer patients who underwent radical thyroid cancer treatment in our hospital from March 2021 to March 2023 were retrospectively analysed and divided into the recurrence group(n=27)and the non-recurrence group(n=83)according to the follow-up results.General information,serum TG,TSH and TG/TSH levels were compared between the two groups.Multifactorial logistic regression was used to analyse the influencing factors of recurrence after radical surgery for thyroid cancer and the value of serum TG and TG/TSH levels in predicting recurrence after radical surgery for thyroid cancer was analysed by receiver operating characteristic(ROC)curve.Results The percentage of clinical stage Ⅱ,the percentage of lymph node metastasis and the levels of TG and TG/TSH in the two groups were compared,and the differences were statistically significant(P<0.05).Multifactorial logistic regression analysis showed that the percentage of clinical stage Ⅱ,the percentage of lymph node metastasis and the levels of TG and TG/TSH were the influencing factors for the recurrence of thyroid cancer after radical thyroid cancer treatment(P<0.05).The levels of TG,TG/TSH predicted the value of serum TG and TG/TSH levels for predicting the recurrence of thyroid cancer after radical thyroid cancer treatment by ROC curve.TSH levels predicted the area under the curve of 0.745 and 0.892 for recurrence after radical thyroid cancer surgery,respectively(P<0.05).Conclusion There are many factors affecting the recurrence of thyroid cancer after radical surgery,including clinical stage,percentage of lymph node metastasis and TG,TG/TSH levels,and the higher the preoperative TG,TG/TSH levels of the patients,the higher the risk of recurrence of the patients.