首页|术前血清TG/TSH水平预测甲状腺癌根治术后复发风险的价值

术前血清TG/TSH水平预测甲状腺癌根治术后复发风险的价值

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目的 探讨术前血清甲状腺球蛋白(TG)/促甲状腺激素(TSH)水平预测甲状腺癌根治术后复发风险的价值。方法 回顾性分析2021年3月至2023年3月本院接受甲状腺癌根治术治疗的110例甲状腺癌患者临床资料,根据随访结果分为复发组(n=27)和未复发组(n=83)。比较两组一般资料、血清TG、TSH及TG/TSH水平。采用多因素Logistic回归分析甲状腺癌根治术后复发的影响因素并通过ROC曲线分析血清TG、TG/TSH水平预测甲状腺癌根治术后复发的价值。结果 两组临床分期Ⅱ期占比、淋巴转移占比及TG、TG/TSH水平比较,差异有统计学意义(P<0。05);多因素Logistic回归分析显示临床分期Ⅱ期占比、淋巴转移占比及TG、TG/TSH水平为甲状腺癌根治术后复发的影响因素(P<0。05);TG、TG/TSH水平预测甲状腺癌根治术后复发情况的曲线下面积分别为0。745、0。892(P<0。05)。结论 影响甲状腺癌根治术后复发的因素较多,包括临床分期、淋巴转移占比及TG、TG/TSH水平,患者术前TG、TG/TSH水平越高患者复发风险越高。
Objective To investigate the value of preoperative serum thyroglobulin(TG)/thyroid-stimulating hormone(TSH)levels in predicting the risk of recurrence after radical thyroid cancer surgery.Methods The clinical data of 110 thyroid cancer patients who underwent radical thyroid cancer treatment in our hospital from March 2021 to March 2023 were retrospectively analysed and divided into the recurrence group(n=27)and the non-recurrence group(n=83)according to the follow-up results.General information,serum TG,TSH and TG/TSH levels were compared between the two groups.Multifactorial logistic regression was used to analyse the influencing factors of recurrence after radical surgery for thyroid cancer and the value of serum TG and TG/TSH levels in predicting recurrence after radical surgery for thyroid cancer was analysed by receiver operating characteristic(ROC)curve.Results The percentage of clinical stage Ⅱ,the percentage of lymph node metastasis and the levels of TG and TG/TSH in the two groups were compared,and the differences were statistically significant(P<0.05).Multifactorial logistic regression analysis showed that the percentage of clinical stage Ⅱ,the percentage of lymph node metastasis and the levels of TG and TG/TSH were the influencing factors for the recurrence of thyroid cancer after radical thyroid cancer treatment(P<0.05).The levels of TG,TG/TSH predicted the value of serum TG and TG/TSH levels for predicting the recurrence of thyroid cancer after radical thyroid cancer treatment by ROC curve.TSH levels predicted the area under the curve of 0.745 and 0.892 for recurrence after radical thyroid cancer surgery,respectively(P<0.05).Conclusion There are many factors affecting the recurrence of thyroid cancer after radical surgery,including clinical stage,percentage of lymph node metastasis and TG,TG/TSH levels,and the higher the preoperative TG,TG/TSH levels of the patients,the higher the risk of recurrence of the patients.

ThyroglobulinThyroid stimulating hormoneThyroid cancerRadical operationRecurrence risk

李婷婷、徐敏敏、李志安、童海江

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312000 浙江省绍兴第二医院医共体总院

甲状腺球蛋白 促甲状腺激素 甲状腺癌 根治术 复发风险

2024

浙江临床医学
浙江中医药大学 浙江省科普作家协会医学卫生委员会

浙江临床医学

影响因子:0.52
ISSN:1008-7664
年,卷(期):2024.26(10)