Objective To Explore the relationship between the all-cause mortality during hospital stay and the erythrocyte distribution width to albumin ratio(RAR)in sepsis patients with acute respiratory failure(ARF)in the intensive care unit(ICU).Methods A retrospective analysis was conducted on adult patients diagnosed with sepsis combined with ARF admitted to the ICU from the Medical Information Mart for Intensive Care(MIMIC-Ⅳ),totaling 4,348 individuals.Patients were divided into survivors and non-survivors based on the outcomes during their hospital stay.Kaplan-Meier(K-M)survival curves were plotted based on the outcomes at 30 days of hospitalization to evaluate survival risks.A multifactorial Cox regression model was constructed to assess whether the RAR value is an independent risk factor for all-cause mortality in sepsis patients with ARF during their ICU stay.Results The non-survivor group had higher levels of age,red cell distribution width (RDW),base excess,white blood cells,creatinine,prothrombin time,SOFA score,potassium,and magnesium compared to the survivor group. The levels of Albumin (Alb),hemoglobin,and platelets were lower in the non-survivor group. There were more patients undergoing mechanical ventilation and with comorbidities such as liver cirrhosis,acute myocardial infarction,and acute kidney injury in the non-survivor group than in the survivor group. The RAR value was significantly higher in the non-survivor group compared to the survivor group (P<0.05). The K-M survival curves indicated that the higher the RAR,the lower the 30-day cumulative survival rate (x2=49.380,P<0.001). Multifactorial Cox regression analysis showed that a high RAR (>6.00％) was an independent risk factor for all-cause mortality in sepsis patients with ARF during their ICU stay(HR=1.320,95％CI:1.095～1.591,P<0.004).Conclusion The RAR level at ICU admission can serve as an independent prognostic factor for mortality in sepsis patients with ARF.In clinical practice,the RAR value can be used to predict the prognosis in the early stages of the disease,which plays a warning role in the clinical assessment of disease severity.
Red cell distribution width to albumin ratioSepsis patients with acute respiratory failurePrognosis
万方数据
维普
