Objective To explore the efficacy and influencing factors of sacral neuromodulation combined with pelvic floor electromyography stimulation in the treatment of myofascial pelvic pain syndrome(MPPS).Methods A retrospective analysis was conducted on 167 patients with MPPS who received sacral neuromodulation combined with pelvic floor electromyography stimulation treatment at Jiaxing Maternal and Child Health Hospital from March 2021 to March 2023.Clinical data before and after treatment were compared,including Glazer assessment of pelvic floor surface electromyography,visual analog scale(VAS)for pelvic floor muscle tenderness,and Female Sexual Function Index(FSFI).Univariate and multivariate analyses were used to select 13 variables that affect the treatment outcome of MPPS.Results After treatment,there were 36 cases of significant improvement,69 cases of effectiveness,and 52 cases of no effect,with a total effective rate of 62.9%.The Glazer assessment indicated a significant decrease in pre-resting potential,post-resting potential,and fast muscle recovery time after treatment,along with an increase in the total score.The VAS score decreased,and the FSFI score increased,with statistically significant differences(P<0.05).Univariate analysis found that age ≥40 years,body mass index (BMI)≥24 kg/m2,disease course ≥1 year,parity ≥2 times,history of abortion,large-for-gestational-age infants or twins,and a pre-treatment VAS score of pelvic floor muscle tenderness<7 were high-risk factors affecting the efficacy of MPPS treatment.Multivariate analysis confirmed that age ≥40 years,BMI ≥24 kg/m2,large-for-gestational-age infants or twins,history of abortion,and a pre-treatment VAS score of pelvic floor muscle tenderness<7 were independent risk factors affecting the efficacy of MPPS treatment.Conclusion The combination of sacral neuromodulation and pelvic floor electromyography stimulation is significantly effective in treating MPPS,and its efficacy is influenced by factors such as age,BMI,large-for-gestational-age infants or twins,history of abortion,and the degree of pre-treatment pelvic floor muscle tenderness.