Objective To analyze the clinical distribution characteristics of Klebsiella pneumoniae(KPN)and carbapenem-resistant Klebsiella pneumoniae(CRKP)in hospitalized patients,and to explore the trend of their resistance to antimicrobial agents,in order to provide a basis for the clinical selection of appropriate antimicrobial drugs.Methods Clinically isolated KPN and CRKP data from 2018 to 2022 were collected,and the epidemiological characteristics of patients,specimen sources,department distribution,drug sensitivity results,and changes in resistance to commonly used antibiotics were retrospectively analyzed using WHONET 5.6 and SPSS 25.0 software.Results A total of 5,654 non-duplicate KPN strains were isolated from 2018 to 2022.The main sources of specimens were sputum(54％),pus(10％),and urine(9％).The distribution was mainly concentrated in the intensive care unit(17％),hepatobiliary surgery(13％),and respiratory department(10％).The resistance rates of KPN to cefazolin,meropenem,and amikacin were 21.8％,4.5％,and 3.5％,respectively.From 2019 to 2021,the resistance of KPN to common clinical antibiotics and carbapenems showed a downward trend,such as imipenem and meropenem.A total of 339 CRKP strains were isolated from 2018 to 2022,with a decreasing detection rate.The main sources of specimens were sputum(54％),urine(13％),and blood(9％).The departments were mainly intensive care unit(40％),critical care rehabilitation(9％),and hepatobiliary surgery(8％).CRKP showed high resistance to cephalosporins and other commonly used β-lactam antibiotics,moderate resistance to amikacin and co-trimoxazole,and was more sensitive to tigecycline.Patients infected with these two types of pathogens were mainly elderly males aged ≥60 years,with the highest detection rate in summer.Conclusion From 2018 to 2022,the resistance rates of KPN and CRKP strains isolated in the hospital to most antimicrobial drugs showed an overall trend of first rising and then falling.Regular observation of bacterial resistance is crucial for understanding its changing trends and is of great significance for preventing and controlling the emergence and spread of CRKP.
万方数据
维普
