Objective To investigate the multi-detector spiral computed tomography findings of chromophobe renal cell carcinoma and to improve the imaging diagnostic ability of chromophobe renal cell carcinoma.Methods The clinical and imaging data of 8 patients with chromophobe renal cell carcinoma confirmed by surgical pathology from January 2015 to September 2023 were retrospectively analyzed,and the imaging findings were summarized. Results Among the 8 patients,6 were females and 2 were males,with an average age of(46±4.7)years.4 cases were located in the left kidney,and 4 in the right kidney,the imaging findings were as followed:5 were circular and regular,3 were irregular.6 were exogenous and 2 were endogenous.CT plain scan density was uniform in 5 cases,including 4 cases with isodensity and 1 case with slightly low density,no necrosis,calcification or bleeding was observed.3 cases showed mixed density with necrosis and calcification.The enhanced scan showed uneven enhancement in 6 cases and uniform enhancement in 2 cases,1 case showed mild enhancement,3 cases showed moderate enhancement,and 4 cases showed obvious enhancement,and the enhancement degree of each stage was lower than that of renal cortex.The peak value of enhancement occurred in arterial phase in 2 cases,portal phase in 5 cases and venous phase in 1 case. In 6 patients,there were multiple vascular shadows in the lesion,with delayed enhancement of central scar in 1 case and septal enhancement in 1 case.Capsule was seen in 2 cases.Conclusion Chromophobe cell carcinoma usually shows equal or slightly low density mass on plain CT scan,which may be combined with necrosis and calcification. The enhancement methods are various,and the enhancement at each stage is lower than that of normal renal cortex,showing relatively deficient blood supply tumor,vascular enhancement and delayed enhancement of central scar are seen in the tumor.