Objective To explore the diagnostic value of ultrasound imaging for breast cancer with neuroendocrine features.Methods A retrospective analysis was conducted on 36 patients with neuroendocrine-featured breast cancer treated at our hospital from 2011 to 2021.Preoperative ultrasound images,clinical,and pathological outcome data were analyzed for their correlation with neuroendocrine-featured breast cancer.Results Among the 36 patients,well-differentiated neuroendocrine tumors accounted for 13.9％,poorly differentiated neuroendocrine carcinomas for 5.5％,and invasive breast cancers with neuroendocrine features for 80.6％.Ultrasound characteristics included irregular shape(91.7％),parallel growth(83.3％),hypoechoic( 94.4％),irregular margins(83.3％),no change in posterior echo(69.4％),no calcification(77.8％),and blood flow signals of grade Ⅱ-Ⅲ(61.1％).BI-RADS classifications were 4A(41.7％),4B(22.2％),4C(25％),and 5(11.1％).Postmenopausal status was observed in 72.2％ of patients,and the positive rate of lymph node metastasis was 25％.Immunohistochemical testing showed positive rates of 94.4％ for ER and PR,11.1％ for HER-2,86.1％ for CgA,and 100％ for Syn.The Ki-67 proliferation index ranged from 2％ to 90％.Receiver operating characteristic (ROC) curves indicated low diagnostic efficacy of the variables(AUC:0.365～0.640),and multivariate logistic regression analysis did not identify independent predictive factors.Conclusion Ultrasound examination has a high detection rate for breast cancer with neuroendocrine features,but ultrasound image characteristics cannot predict different pathological types at an early stage.
Breast neuroendocrine carcinomaUltrasonic diagnosisPathological diagnosisImmunological histochemistry
万方数据
维普
