Object To elucidate the effect caused by dopamine administrated during anesthesia induction for gastrointestinal endoscopy on intraoperative circulation and postoperative cognitive function in elderly patients.Methods Total 60 cases of elderly patients who underwent painless gastroenteroscopy from January 2022 to June 2022 were selected and randomly divided into the control group and the observation group,30 cases in each group,the observation group was given dopamine 2 mg(1 mg/mL)at the time of induction,and the control group was given the same dose of saline,and the changes in circulation during anaesthesia as well as in postoperative cognitive scores were compared between the two groups.Results Cognitive scores,incidence of short-term postoperative cognitive dysfunction (POCD) within 30 min after painless gastroenteroscopy,and post-induction circulation were compared between the two groups,and the differences were statistically significant(P<0.05);the dobutamine group was more stable compared with the control group(P<0.05).Conclusion The application of dopamine in the anesthesia for painless gastrointestinal endoscopy can mitigate hemodynamic fluctuation and POCD.