Objective To explore the application effect of the closed suction catheter cavity irrigator in critically ill patients with artificial airway undergoing mechanical ventilation.Methods Using a convenience sampling method,84 patients who received mechanical ventilation treatment through an artificial airway in our department from January 2021 to December 2021 were selected as the control group.The traditional irrigation method was used for suction,which involved using a syringe to draw up physiological saline and connecting it to the water inlet of the closed suction catheter.From January 2022 to December 2022,84 patients who received mechanical ventilation treatment through an artificial airway in our department were selected as the experimental group,and the closed suction catheter cavity irrigator was used for irrigation.The differences in liquid splash and leakage pollution rate,time consumed for single suction of the artificial airway,and tidal volume between the two groups were compared.Results No liquid splash and leakage pollution occurred during the operation in the experimental group,while the pollution rate was 40.48% in the control group.The difference between the two groups was statistically significant(P<0.05).The time consumed for single suction of the artificial airway in the experimental group was less than that in the control group,with averages of(7.45±1.48)seconds and(27.46±5.08)seconds,respectively.The difference between the two groups was statistically significant(P<0.05).The tidal volume before irrigation in the experimental group was higher than that in the control group,with averages of(0.436±0.053)L and(0.351±0.060)L,respectively.The difference between the two groups was statistically significant(P<0.05).Conclusion The application of the closed suction catheter cavity irrigator effectively avoids the phenomenon of liquid splash and leakage during the irrigation operation,complys with the principles of aseptic operation,reduces the risk of cross-infection,improves work efficiency,and helps maintain the stability of respiratory machine treatment.