首页|表观遗传机制在原发性高血压中的作用及针刺干预研究

表观遗传机制在原发性高血压中的作用及针刺干预研究

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检索近年来国内外相关文献,研究表观修饰对原发性高血压的调控机制以及针刺通过表观遗传修饰干预原发性高血压的现状.探讨表观遗传学通过DNA甲基化、组蛋白、非编码RNA及m6A修饰等方面调控原发性高血压的发生与发展.目前,针刺降压被临床广泛应用,但针刺基于表观遗传机制降压的研究较少且仍处于初级阶段.本研究以表观遗传视角探究针刺降压机制,以期为针刺降压提供更多分子生物学依据,为靶向治疗原发性高血压提供新方向、新视角.
Role of Epigenetic Mechanisms in Essential Hypertension and Study on Acupuncture Intervention
The relevant literature at home and abroad in recent years were retrieved in terms of regulatory mechanisms of epigenetic modification on essential hypertension and the current situation and prospect of acupuncture intervention for essential hypertension through epigenetic modification.It is explored that epigenetics regulates the occurrence and development of essential hypertension through DNA methylation,histone,non-coding RNA,and m6A modification.At present,acupuncture for hypotension is widely used in clinic,but the research on acupuncture for hypertension based on epigenetic mechanism is less and still in the initial stage.This study explored the mechanisms of acupuncture for hypertension from the perspective of epigenetics in order to provide more molecular biological bases and to provide a new direction and perspective for targeted treatment of essential hypertension.

Essential hypertensionAcupunctureEpigenetic

董新蕾、燕虹宇、史维霞、闫钦风、汶健、张丽丽

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天津中医药大学第一附属医院,天津 300193

国家中医针灸临床医学研究中心,天津 300381

天津市针灸学重点实验室,天津 300073

原发性高血压 针刺 表观遗传

国家自然科学基金青年项目

82205257

2024

针灸临床杂志
中华中医药学会 黑龙江中医药大学 中国针灸学会临床分会

针灸临床杂志

CSTPCD
影响因子:1.242
ISSN:1005-0779
年,卷(期):2024.40(1)
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