Objective:To observe the clinical effect of fire needling combined with hip-knee training in treatment of knee osteoarthritis(KOA).Methods:60 patients with KOA were randomly divided into the observation group and the control group.The control group was treated with fire needling;on which basis,the observation group was also treated with hip-knee training.10 times of treatment were taken as one course of treatment,both groups were treated for 2 courses of 40 days.The patients were followed up 3 months after the treatment.The pain visual analogue scale(VAS)score,Western Ontario McMaster University osteoarthritis index(WOMAC)score,range of motion(ROM)and serum levels of TNF-α and IL-1 β were used as efficacy criteria.Results:There were no significant differences in general data,VAS score,WOMAC score,ROM and serum levels of TNF-α and IL-1 β between the two groups before the treatment(P>0.05).After the treatment,VAS score,WOMAC score,ROM and serum levels of TNF-α and IL-1β were improved compared with those before the treatment in the two groups(P<0.05),of which the improvements were more significant in the observation group than those in the control group(P<0.01).Conclusion:Fire needling combined with hip-knee training can relieve pain and stiffness symptoms in KOA patients,it can improve joint function and knee joint mobility,and reduce serum levels of TNF-α and II.-1β.