MRI Study of Acupuncture-Induced Brain Activation in Patients with IBS:An Analysis Based on Activation Likelihood Estimation
Objective:To explore the characteristics of brain activation in gastrointestinal-related regions in patients with irritable bowel syndrome(IBS)using activation likelihood estimation(ALE)analysis,and to elucidate the neural mechanisms of brain activity changes in IBS patients after acupuncture treatment.Methods:Chinese and foreign databases were systematically searched from the establishment to May 2023.Coordinate standardization and meta-analysis were performed using Ginger-ALE 3.0.2 software.The brain ALE distribution maps were presented using Micron and Dpabi software.Results:8 studies were included,comprising 248 IBS cases and 149 healthy controls.Meta-analysis results showed that compared with healthy controls,IBS patients exhibited increased activation in the right inferior frontal gyrus,right middle frontal gyrus,right lentiform nucleus,right thalamus,and right insula,with no decreased activation in any brain regions.After acupuncture treatment,IBS patients showed decreased activation in the left middle frontal gyrus,left lentiform nucleus,left precentral gyrus,left parahippocampal gyrus,and left cingulate gyrus compared to pre-treatment levels.Further comparative analysis revealed that the lentiform nucleus was a commonly activated brain region during acupuncture treatment.Conclusion:IBS patients exhibit alterations in neural metabolism in relevant brain regions.Acupuncture can overall regulate the functional activity of dominant brain regions in IBS patients,thereby modulating gastrointestinal disorders.
万方数据
维普
