Role of Peripheral Neuroimmune Interaction in Anti-Inflammatory and Analgesic Effects of Acupuncture
Inflammation is a common physiological process.Suitable inflammation can protect the body and is of great significance for maintaining body health.However,excessive inflammation can cause inflammatory pain,and cause harm to patients.How to safely and effectively alleviate inflammatory pain is a hot topic in medical research today.Acupuncture,as a kind of treatment method of traditional Chinese medicine,has significant anti-inflammatory and analgesic effects,meanwhile possessing the characteristics of safety and no side effects.The autonomic nerve mediates the anti-inflammatory effect of acupuncture.Acupuncture affects the release of various neurotransmitters,including catecholamine,by regulating the activities of vagus nerve and sympathetic nervous system.It influences neurotransmitters to bind to receptors on immune cells and affects immune cells to regulate inflammation.It can also affect the level of analgesic substances and their receptors expressions.Analgesics not only participate in the production and transmission of pain information,but also regulate the activation of immune cells and affect the level of inflammatory factors.The nervous system,immune system,and their interactions are involved in the inflammatory pain.Acupuncture exerts anti-inflammatory and analgesic effects through peripheral neuroimmune interactions,and serves as a safe and effective method for alleviating inflammatory pain in clinical practice.
AcupunctureAnti-inflammatory and analgesic effectsNeuro-immune interaction