首页|外周神经免疫互作在针刺抗炎镇痛中的作用

外周神经免疫互作在针刺抗炎镇痛中的作用

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炎症是一种常见的生理反应,适度的炎症反应可以保护机体,对维持机体健康具有重要意义,但过度的炎症反应则会引起炎性痛,给患者造成伤害,如何安全有效地减轻炎性痛是当今医学研究的热点.针刺作为传统中医的一种治疗手段,拥有显著的抗炎镇痛疗效,同时兼具安全无副作用的特点.自主神经介导了针刺的抗炎效应,针刺通过调节迷走神经和交感神经的活性,影响儿茶酚胺在内的多种神经递质释放,影响神经递质与免疫细胞上的受体结合,通过调节免疫细胞影响炎症反应;针刺也能够影响镇痛物质的水平及其受体表达,镇痛物质不仅参与疼痛信息的产生及传递过程,也可以调控免疫细胞的活化,影响促炎介质的水平.神经、免疫系统及其相互作用参与了炎性痛的产生过程,针刺通过外周神经免疫互作发挥抗炎镇痛效应,在临床上可作为一种安全有效的减轻炎性痛的方法.
Role of Peripheral Neuroimmune Interaction in Anti-Inflammatory and Analgesic Effects of Acupuncture
Inflammation is a common physiological process.Suitable inflammation can protect the body and is of great significance for maintaining body health.However,excessive inflammation can cause inflammatory pain,and cause harm to patients.How to safely and effectively alleviate inflammatory pain is a hot topic in medical research today.Acupuncture,as a kind of treatment method of traditional Chinese medicine,has significant anti-inflammatory and analgesic effects,meanwhile possessing the characteristics of safety and no side effects.The autonomic nerve mediates the anti-inflammatory effect of acupuncture.Acupuncture affects the release of various neurotransmitters,including catecholamine,by regulating the activities of vagus nerve and sympathetic nervous system.It influences neurotransmitters to bind to receptors on immune cells and affects immune cells to regulate inflammation.It can also affect the level of analgesic substances and their receptors expressions.Analgesics not only participate in the production and transmission of pain information,but also regulate the activation of immune cells and affect the level of inflammatory factors.The nervous system,immune system,and their interactions are involved in the inflammatory pain.Acupuncture exerts anti-inflammatory and analgesic effects through peripheral neuroimmune interactions,and serves as a safe and effective method for alleviating inflammatory pain in clinical practice.

AcupunctureAnti-inflammatory and analgesic effectsNeuro-immune interaction

桂勇青、徐枝芳、李亚男、谢飞、章明星、郭义、公一囡

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天津中医药大学实验针灸学研究中心,天津 301617

天津中医药大学,天津 301617

天津市现代中医理论创新转化重点实验室,天津 301617

潍坊市益都中心医院,山东潍坊 262500

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针刺 抗炎镇痛 神经免疫互作

国家自然科学基金重点项目国家自然科学基金青年基金天津市教委科研项目

82030125822052792021KJ121

2024

针灸临床杂志
中华中医药学会 黑龙江中医药大学 中国针灸学会临床分会

针灸临床杂志

CSTPCD
影响因子:1.242
ISSN:1005-0779
年,卷(期):2024.40(4)