Research Progress on Mechanism of Acupuncture Treating CIS Based on Astrocytes
Astrocytes(AS),as the most abundant glial cells in the nervous system,are closely related to nerves,blood vessels and other glial cells,and play an important role in the occurrence and development of cerebral ischemic stroke(CIS).Acupuncture therapy has the characteristics of multi-target and multi-way regulation.The overall regulatory effects of acupuncture on AS is shown in the following ways,including inhibiting AS activation,promoting AS proliferation and inhibiting AS overproliferation,and benefiting the stability of AS ultrastructure.Taking AS as target,this study summarized the relevant mechanism of acupuncture in treatment of CIS from the aspects of promoting nerve repair and regeneration,regulating excitatory amino acid metabolism,regulating energy metabolism,regulating vascular regeneration,reducing oxidation reaction,reducing inflammation,regulating cell communication,inhibiting brain edema,promoting neural stem cell differentiation,and inhibiting glial scar overgeneration,aiming to provide reference for related research in the future.
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