针灸临床杂志2024,Vol.40Issue(5) :81-86.DOI:10.19917/j.cnki.1005-0779.024098

基于肠道微生物菌群探讨针灸治疗肠易激综合征的效应机制

Mechanism Exploration of Acupuncture and Moxibustion in Treatment of IBS Based on Gut Microbiota

王海强 王思颖 李冰琪 张萌 王瑶 郑丽红
针灸临床杂志2024,Vol.40Issue(5) :81-86.DOI:10.19917/j.cnki.1005-0779.024098

基于肠道微生物菌群探讨针灸治疗肠易激综合征的效应机制

Mechanism Exploration of Acupuncture and Moxibustion in Treatment of IBS Based on Gut Microbiota

王海强 1王思颖 2李冰琪 2张萌 2王瑶 1郑丽红3
扫码查看

作者信息

  • 1. 黑龙江中医药大学附属第一医院,黑龙江哈尔滨 150040
  • 2. 黑龙江中医药大学,黑龙江哈尔滨 150040
  • 3. 黑龙江中医药大学附属第四医院,黑龙江哈尔滨 150070
  • 折叠

摘要

肠易激综合征是功能性胃肠病中最常见的一种,其病理生理机制非常复杂.近年来,肠道菌群在肠易激综合征相关研究中发挥了重要作用,肠道微生态失衡、菌群组成及多样性改变、有益菌减少而有害菌增加导致了疾病发生发展,以肠道菌群为导向的治疗手段也逐渐增多.同时,由于药物干预未能取得满意的疗效,在寻求替代疗法的过程中,针灸因其应用广泛、不良反应少而备受关注.相关研究表明针灸可以通过影响肠道菌群来调节肠道功能,改善肠易激综合征的症状.因此,本研究旨在论述肠道菌群与肠易激综合征的关系,并从调节肠道菌群的角度探讨针灸治疗肠易激综合征的效应机制.

Abstract

Irritable bowel syndrome(IBS)is one of the most common functional gastrointestinal disorder,and its pathophysiological mechanisms are very complicated.In recent years,the role of gut microbiota in IBS-related research has been significant.Dysbiosis of gut microbiota,changes in microbial composition and diversity,reduction of beneficial bacteria,and increase of harmful bacteria contribute to the development and progression of the disease.Therefore,treatment strategies targeting gut microbiota have gradually increased.Meanwhile,due to unsatisfactory results with medication intervention,acupuncture and moxibustion has garnered attention as an alternative therapy because of its wide application and minimal adverse effects.Studies have shown that acupuncture can regulate intestinal function and improve symptoms of IBS by influencing gut microbiota.This study aims to discuss the relationship between gut microbiota and IBS,and to explore the mechanism of acupuncture treatment for IBS from the perspective of modulating gut microbiota.

关键词

肠易激综合征/肠道菌群/针灸/胃肠疾病/脑-肠轴

Key words

Irritable bowel syndrome/Gut microbiota/Acupuncture and moxibustion/Gastrointestinal diseases/Brain-gut axis

引用本文复制引用

基金项目

国家中医药局全国中医临床优秀人才研修项目(第五批)(国中医药人教函[2022]1号)

黑龙江中医药大学"优秀青年骨干教师"计划(15041190018)

黑龙江中医药大学研究生创新科研项目(2020yjscx014)

黑龙江中医药大学科研面上项目(2019MS02)

出版年

2024
针灸临床杂志
中华中医药学会 黑龙江中医药大学 中国针灸学会临床分会

针灸临床杂志

CSTPCD
影响因子:1.242
ISSN:1005-0779
参考文献量48
段落导航相关论文