摘要
心律失常是心血管系统的多发病,恶性心律失常更是导致心源性猝死的高危因素.针刺治疗具有简易、便廉、安全与有效的特点,不仅能控制心律失常,而且副作用小,在临床上能作为心律失常的辅助治疗手段.本研究通过梳理国内外针刺防治心律失常的相关研究,总结出针刺能通过调节神经活动、抑制钙超载、抑制细胞自噬和凋亡、抑制炎症反应和调节内分泌等多种途径对抗心律失常,其相关机制与下丘脑外侧区(LHA)-小脑顶核(FN)神经环路、蓝斑核(LC)、血管活性肠肽(VIP)、k-阿片受体(k-OR)信号通路、线粒体活性氧(ROS)升高与磷脂酰肌醇-3-激酶(PI3K)/蛋白激酶B(Akt)信号通路、调控炎症基因和α1A-肾上腺素能受体(α1A-AR)等有关,期望为针刺治疗心律失常的作用机制提供新的视角.
Abstract
Cardiac arrhythmia is a common cardiovascular disorder,with malignant arrhythmias being a high-risk factor for sudden cardiac death.Acupuncture therapy is characterized by its simplicity,convenience,safety and effectiveness.It not only helps control arrhythmias,but also has minimal side effects,making it a viable adjunctive treatment option in clinical practice.By reviewing relevant researches on acupuncture for the prevention and treatment of arrhythmias both domestically and abroad,this study summarized that acupuncture can counteract arrhythmias through various pathways,including modulation of neural activity,inhibition of calcium overload,suppression of cellular autophagy and apoptosis,inhibition of inflammatory responses,and regulation of endocrine function.The underlying mechanisms involve the signaling pathways of lateral hypothalamic area(LHA)-fastigial nucleus(FN)neural circuit,locus coeruleus(LC),vasoactive intestinal peptide(VIP),k-opioid receptor(k-OR),elevation of mitochondrial reactive oxygen species(ROS),signaling pathway of phosphatidylinositide 3-kinases(PI3K)/protein kinase B(Akt),regulation of inflammatory genes,and α1 A-adrenergic receptor(α1 A-AR).This study aims to provide theoretical basis for the mechanism of acupuncture in treating arrhythmias.
基金项目
国家自然科学基金地区科学基金(82160887)
广西壮族自治区岐黄学者培养项目(2022015-003-02)
广西自然科学基金面上项目(2021GXNSFAA220111)
广西自然科学基金青年基金(2021GXNSFBA196018)
维普
万方数据