首页|方氏头针结合子午流注纳子法对失眠患者血清GABA、Glu及睡眠质量的影响

方氏头针结合子午流注纳子法对失眠患者血清GABA、Glu及睡眠质量的影响

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目的:探索方氏头针结合子午流注纳子法治疗失眠症的疗效,并探讨其可能的机制.方法:选择60例失眠症患者随机分为观察组(30例)和对照组(30例,脱落1例).对照组给予常规针刺,观察组给予方氏头针结合子午流注纳子法针刺治疗.两组患者1次/d,每周5次,连续2周.分别于治疗前后评定匹兹堡睡眠质量指数量表(PSQI)评分、血清γ-氨基丁酸(GABA)及谷氨酸(Glu)的变化情况.结果:治疗2周,两组患者PSQI均较治疗前下降,差异有统计学意义(P＜0.05).治疗后血清GABA水平较治疗前比较均有所上升,Glu水平较治疗前比较均有所下降.方氏头针联合子午流注纳子法组在血清GABA水平上与常规针刺组比较,差异具有统计学意义(P＜0.05).结论:方氏头针结合子午流注纳子法治疗失眠确有疗效,能够明显地改善患者的临床症状,其机制可能与调节血清GABA、Glu水平有关.
Effect of Fang's Scalp Acupuncture Combined with Nazi Method of Midnight-Noon Ebb-Flow on Serum GABA and Glu and Sleep Quality in Patients with Insomnia
Objective:To explore the therapeutic efficacy of Fang's scalp acupuncture combined with Nazi method of midnight-noon ebb-flow in treatment of insomnia,and to explore its possible mechanisms.Methods:60 patients with insomnia were randomly divided into the observation group(n=30)and the control group(n=30,one case dropping out).The control group was treated with conventional acupuncture,whereas the observation group was treated with Fang's scalp acupuncture combined with Nazi method of midnight-noon ebb-flow.Both groups were needled once a day,5 times a week for 2 weeks.The score of Pittsburgh Sleep Quality Index(PSQI),and the serum levels of γ-aminobutyric acid(GABA)and glutamate(Glu)were assessed before and after the treatment in the two groups.Results:After 2 weeks of treatment,the score of PSQI was significantly decreased in both groups compared to that before the treatment in the two groups;the serum level of GABA was increased and the serum level of Glu was decreased compared to that before the treatment in the two groups.There was a statistical difference in the serum level of GABA between the two groups after the treatment(P＜0.05).Conclusion:Fang's scalp acupuncture combined with Nazi method of midnight-noon ebb-flow is indeed efficacious in treatment of insomnia,it can significantly improve the clinical symptoms,and its mechanism may be related to the regulation of serum levels of GABA and Glu.

InsomniaFang's scalp acupunctureNazi method of midnight-noon ebb-flowGABAGluRandomized controlled trial

刘媛媛、安琪、安军明、刘艳芳、马凯靖、赵镇涛

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陕西中医药大学,陕西咸阳 712000

北京中医药大学,北京 100029

西安市中医医院,陕西西安 710021

失眠 方氏头针 子午流注纳子法 γ-氨基丁酸 谷氨酸 随机对照试验

陕西省科技厅社会发展领域项目陕西省中医药管理局重点科研项目陕西省中医药管理局方氏头针重点研究室项目陕西省中医药管理局长安方氏头针流派传承工作室项目西安市地方级领军人才项目

2021SF-2822021-01-22-007陕中医药发[2018]32号陕中医药发[2018]40号XARC210159

2024

10.19917/j.cnki.1005-0779.024113

针灸临床杂志
中华中医药学会 黑龙江中医药大学 中国针灸学会临床分会

针灸临床杂志

CSTPCD
影响因子：1.242
ISSN：1005-0779
年,卷(期)：2024.40(6)
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