Exploration of Acupuncture Analgesic Mechanism Based on Spinal Microglial Cell Polarization
The spinal cord serves as a hub for transmitting,perceiving and modulating nociceptive information in pain.Spinal cord microglia,a type of non-neuronal cell with immune and regulatory functions,can be activated during pain processes,exhibiting activation responses similar to marcrophage polarization.This polarization process can promote microglia to release various neurotransmitters and cytokines,thereby participating in neuroinflammation and pain perception,contributing to the occurrence and maintenance of pain.Acupuncture is an effective analgesic therapy,and the spinal cord is an important component in research on the mechanism of acupuncture analgesia.Research has shown that acupuncture can modulate the polarization of spinal cord microglia,affect both the active M1 type and the inhibitory M2 type,thus reducing neuroinflammation,and alleviating central sensitization.This study reviewed the mechanism by which acupuncture regulates the polarization of spinal cord microglia to exert analgesic effects,thus to provide basis for future studies on acupuncture analgesia.
PainSpinal cordPolarization of microgliaAcupuncture analgesia
万方数据
维普
