首页|针刺治疗多囊卵巢综合征代谢紊乱的机制研究进展

针刺治疗多囊卵巢综合征代谢紊乱的机制研究进展

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多囊卵巢综合征(PCOS)是涉及多系统多环节的一组综合紊乱症候群,稀发排卵、高雄激素血症和肥胖是其主要临床特征,已严重影响女性生活质量及身心健康.而PCOS性代谢紊乱是加重高雄激素血症及肥胖的重要环节,中医针刺技术在改善PCOS代谢紊乱方面疗效显著.通过文献研究,笔者发现针刺可能通过局部穴位效应改善脾虚水湿停滞及肾虚水泛的病理状态,从而促进机体细胞代谢,作用机制可能与影响IRS-1/PI3K/Akt/GLUT4、下丘脑NFκB及Toll样受体信号通路转导有关.现就研究内容进行详尽阐述,以期为PCOS代谢病因研究提供理论思路.
Mechanisms and Research Progress of Acupuncture in Treating Metabolic Disorders of PCOS
Polycystic ovary syndrome(PCOS)is a group of comprehensive disorders involving multiple systems and links,with sporadic ovulation,hyperandrogenemia and obesity as its main clinical features,which has seriously affected womens'quality of life and physical and mental health.The PCOS metabolic disorder is an important part of aggravating hyperandrogenemia and obesity,and the efficacy of acupuncture is remarkable in improving PCOS metabolic disorder.Through literature research,it is found that acupuncture may improve the pathological state of Spleen deficiency and water-dampness stagnation,and Kidney deficiency and water flooding through the effect of local acupoints,thus promoting the cellular metabolism of the body,and the action mechanism may be related to influencing IRS-1/PI3K/Akt/GLUT4,hypothalamus NFκB and Toll-like receptor signaling pathway transduction.The study is now elaborated to provide theoretical ideas for the study of the etiology of PCOS.

Polycystic ovary syndromeMetabolic disorderAcupunctureInsulin resistance

王可馨、韩亚光、韩亚鹏、韩延华、高艺媛、李怡文、朱小琳

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黑龙江中医药大学,黑龙江哈尔滨 150040

黑龙江中医药大学附属第一医院,黑龙江哈尔滨 150040

黑龙江中医药大学附属第二医院,黑龙江哈尔滨 150001

多囊卵巢综合征 代谢紊乱 针刺 胰岛素抵抗

国家中医药管理局全国中医学术流派传承工作室第二轮建设项目黑龙江省中医药科研课题黑龙江省中医药管理局中医药经典普及化专项课题黑龙江省自然科学基金联合引导项目黑龙江省博士后科研启动金项目

国中医药人教函201962号黑中医药科函[2022]44号ZYW2022-040JJ2023LH0081LBH-Q20057o

2024

10.19917/j.cnki.1005-0779.024163

针灸临床杂志
中华中医药学会 黑龙江中医药大学 中国针灸学会临床分会

针灸临床杂志

CSTPCD
影响因子：1.242
ISSN：1005-0779
年,卷(期)：2024.40(8)