Analysis of Factors Contributing to Refractory Hiccup Following Cerebral Infarction and Treatment Experience with Thumb-Tack Needling Combined with Acupoints Application Therapy
Objective:To explore the influencing factors of refractory hiccup following cerebral infraction and treatment experience with thumb-tack needling combined with acupoints application therapy.Methods:The 68 patients with refractory hiccup following cerebral infarction were randomly divided into the control group(n=34)and the observation group(n=34).The control group was treated with conventional medication;on which basis,the observation group was also treated with thumb-tack needling combined with acupoints application.The clinical characteristics of patients was compared and a multivariate analysis was performed to identify independent factors influencing the development of refractory hiccups following cerebral infraction.An artificial neural network model was constructed and its performance was validated.Changes in various indicators between the two groups of patients were evaluated by using a generalized estimating equation model.Results:Patients in the hiccup group showed significant differences compared to the non-hiccup group in terms of lesion location(brainstem,cerebral cortex),respiratory obstruction,pronounced brain edema,gastrointestinal bleeding,nasogastric tube insertion,severity of the condition,hypocalcemia and hypomagnesia.All these indicators were identified as independent factors influencing the development of refractory hiccups following cerebral infarction(P＜0.05).The artificial neural network model indicated that respiratory obstruction,hypocalcemia,hyponatremia,gastrointestinal bleeding and severity of the condition had high weights.The ROC curve results showed that the artificial neural network model had good discrimination.Using a generalized estimating equation,the impact of the two intervention methods on patients'neural pathway indicators was evaluated.After the intervention,the levels of VC AM-1 and PEC AM-1 significantly increased in both groups,with statistically significant differences(P＜0.05).Additionally,the observation group had significantly higher levels than the control group,and the difference between the two groups was statistically significant(P＜0.05).Conclusion:Refractory hiccup following cerebral infarction is associated with factors such as lesion location,severity of the condition,hypocalcemia and hypomagnesia,which require clinical attention.Additionally,the combination of thumb-tacking needling and acupoints application can effectively improve refractory hiccup symptoms,making it worthy of promotion and application in clinical practice.
万方数据
维普
