Efficacy of Vagal Ganglion Catgut Embedding Combined with Twelve Earthly Branches Umbilical Needling in Treatment of Primary Insomnia and Its Effect on Neurotransmitter Levels
Objective:To observe the clinical effect of vagal ganglion catgut embedding combined with Twelve Earthly Branches umbilical needling in treatment of primary insomnia and its effect on serum neurotransmitters levels.Methods:72 patients with primary insomnia were randomly divided into the treatment group(n=36)and the control group(n=36).The control group was treated with Twelve Earthly Branches umbilical needling;on which basis,the treatment group was also treated with vagus ganglion catgut embedding.The umbilical needling was five times a week for a total of 4 weeks,and the catgut embedding was once every 10 days for a total of 3 times.The sleepiness symptoms[Pittsburgh Sleep Quality Index(PSQI),Epworth Sleepiness Scale(ESS)],neurotransmitter levels[dopamine(DA),glutamate(Glu),norepinephrine(NE),γ-aminobutyric acid(GABA),5-hydroxytryptamine(5-HT),acetylcholine(Ach)],and clinical efficacy were compared between the two groups.Results:The scores of PSQI and ESS were decreased after the treatment compared with those before the treatment in the two groups,and the decreases were more significant in the treatment group(P＜0.01).The serum levels of Glu,GABA and 5-HT were increased after the treatment compared with those before the treatment in the two groups,and the increases were more significant in the treatment group(P＜0.05);the serum levels of Ach,NE and DA were decreased after the treatment compared with those before the treatment in the two groups,and the decreases were more significant in the treatment group(P＜0.01).The total effective rate of the treatment group was 94.29％(33/35),which was significantly higher than 85.30％(29/34)of the control group(P＜0.05).There were no adverse reactions in the two groups during the treatment with high safety.Conclusion:Both therapies can effectively alleviate the clinical syndromes of patients with primary insomnia by increasing the serum levels of Glu,GABA and 5-HT,reducing the serum levels of Ach,NE and DA,and improving sleep quality.The therapeutic effect of vagal ganglion catgut embedding combined with Twelve Earthly Branches umbilical needling is more prominent with its high safety,which is worthy of clinical application and promotion.
万方数据
维普
