Exploring Mechanism of Acupuncture in Treating Post-Stroke Depression Based on BDNF
Post-stroke depression(PSD)is a common depressive state following a stroke episode.Brain-derived neurotrophic factor(BDNF)plays an important role in the pathomechanism of PSD mainly through pathways mediated by high-affinity receptor of the complex kinase receptor B(TrkB),and the low-affinity receptor of p75 neurotrophic factor receptor(p75NTR).Meanwhile,BDNF and PSD are closely related,and low levels of BDNF may enhance patients'susceptibility to PSD.Factors such as stress,DNA methylation,single nucleotide polymorphism(SNP),and neuroinflammation can reduce BDNF levels.In acupuncture treatment of PSD,BDNF mainly plays neuroprotective and neurotrophic roles.The neuroprotective effects were realized through three pathways exerting antioxidant effects,the Nrf2/ARE pathway,the PI3K/Akt pathway and the CREB/BDNF/TrkB pathway.Neurotrophic effects were mainly realized through the following four pathways,the BDNF/TrkB/CREB pathway,the PI3K/Akt/mTORC1 pathway,the MAPK/NF-κB pathway and the tPA/BDNF pathway.The study intends to review the mechanism of acupuncture in treatment of post-stroke depression by activating the neurotrophic and neuroprotective effects of BDNF.
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