Mechanism of Oxidative Stress in CIRI by Acupuncture Intervention
Ischemic stroke is a neurological disease with high incidence,disability,and recurrence rates,posing a common challenge for patients,their families,and clinical practitioners.The progression of stroke is complex,with oxidative stress playing a crucial role in exacerbating cerebral ischemia-reperfusion injury(CIRI)by causing oxidative damage to proteins,DNA,and RNA in the brain,which is extremely detrimental to disease prognosis.Recent studies have shown that acupuncture can significantly inhibit oxidative stress in the ischemic cascade following a stroke.This study explores the mechanisms by which acupuncture intervention alleviates oxidative stress after cerebral ischemia-reperfusion,providing a theoretical basis for using acupuncture as a multi-pathway approach to inhibit oxidative stress and improve prognosis of stroke patients,thereby promoting the rational application of acupuncture in clinical practice.