基于肠-关节轴理论探讨针灸治疗膝关节骨性关节炎
Exploring Acupuncture and Moxibustion Treatment for KOA Based on Gut-Joint Axis Theory
任彩英 1郑洁 2赵莉平1
作者信息
- 1. 陕西中医药大学,陕西咸阳 712046
- 2. 陕西省针药结合重点实验室,陕西咸阳 712046
- 折叠
摘要
肠道微生态失衡时,会诱发机体慢性系统性炎症反应,影响关节部位,针灸可改善肠道微生态,影响多种细胞因子水平从而对关节疾病发挥效应.结合中医脏腑经络理论及现代实验研究,基于脾胃肠腑与关节的生理病理关系以及经络连属关系,以肠道微生物介导的肠-关节轴为切入点,阐明针灸调控肠道微生物群治疗膝骨性关节炎的作用机制,并从调节肠道微生态平衡入手选取腧穴,围绕"肠-关节轴"的角度为针灸治疗膝骨性关节炎的临床诊疗提供新思路.
Abstract
When the gut microbiota becomes imbalanced,it can trigger chronic systemic inflammatory responses,affecting joint areas.Acupuncture and moxibustion have the potential to improve the gut micro-ecosystem and modulate levels of various cytokines,thereby exerting therapeutic effects on joint diseases.Combing TCM theory of Zang-Fu organs and meridian pathways with modern experimental research,and based on the physiological and pathological relationships between Spleen,Stomach,Intestines and joints,as well as their meridian connections,this approach uses the microbiota-mediated gut-joint axis as a starting point.It aims to elucidate the mechanism by which acupuncture and moxibustion regulate gut microbiota to treat knee osteoarthritis(KOA).By selecting acupoints based on the regulation of gut microecological balance and focusing on the gut-joint axis,this provides a new perspective for clinical diagnosis and treatment of KOA.
关键词
肠-关节轴/肠道微生物群/膝关节骨性关节炎/针灸Key words
Gut-joint axis/Gut microflora/Knee osteoarthritis/Acupuncture and moxibustion引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据