针刺调控小胶质细胞减轻神经病理性疼痛的研究进展
Research Progress on Acupuncture Regulating Microglia to Alleviate Neuropathic Pain
范佳佳 1刘涛 1唐甸峰 1白凤媛 1蔡仁军 1徐秋玲1
作者信息
- 1. 海南医学院第一附属医院,海南海口 570102;海南医学院,海南海口 571199
- 折叠
摘要
神经病理性疼痛是慢性疼痛的主要原因之一,严重影响患者的生活质量.小胶质细胞是中枢神经系统的免疫细胞,对维持内环境稳态有重要意义,内环境稳态破坏时,小胶质细胞会迅速活化,根据功能的差异分为M1型和M2型.神经损伤后,小胶质细胞活化产生一系列反应如数量增多、基因转录、产生生物活性因子与吞噬作用等.本研究从针刺作用于小胶质细胞的机制展开论述,阐述针刺镇痛机制,为针刺的镇痛研究提供新思路.
Abstract
Neuropathic pain is one of the primary causes of chronic pain significantly affects patients'quality of life.Microglia,the immune cells of the central nervous system,play a crucial role in maintaining homeostasis.When homeostasis is disrupted,microglia rapidly become activated and are classified into M1 and M2 types based on their functions.After nerve injury,activated microglia undergo various reactions such as proliferation,gene transcription,production of bioactive factors,and phagocytosis,all of which contribute to neuropathic pain.This study explores the mechanisms by which acupuncture affects microglia,elucidating the analgesic mechanism of acupuncture with the aim of providing new insights for research on acupuncture analgeisa.
关键词
神经病理性疼痛/针刺/小胶质细胞/周围神经损伤Key words
Neuropathic pain/Acupuncture/Microglia/Peripheral nerve injury引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据