Fabrication and controlled release characteristics of whey protein-alginate dialdehyde microcapsule
[Objective]This study used whey protein(WPI)and alginate dialdehyde(ADA)to prepare WPI-ADA copolymer microcapsules,and the interactions between WPI and ADA and their effects on the controlled release of curcumin in the microcapsules were investigated to provide a theoretical basis for the development of the encapsulation system of curcumin.[Method]WP1-ADA copolymers were prepared using a wet-heat method,and the interaction between WPI and ADA was explored through analysis of grafting degree,browning intensity,and infrared spectroscopy.The effects of different proportions of copolymers on the emulsion were studied in terms of particle size,zeta potential,and rheological properties.The influence of copolymers on microcapsules was investigated using X-ray diffraction,thermogravimetric analysis,and the release characteristics of curcumin.[Result]The results indicated that the optimum mass ratio of WPI and ADA for preparing microcapsules was 1∶3.Grafting degree,browning intensity and Fourier transform infrared spectroscopy(FTIR)analyses confirmed the formation of conjugates.Driven by covalent binding,the particle size of WPI-ADA emulsion decreased from 415.4 nm to 325.9 nm,and the microcapsule encapsulation efficiency increased from 83.9％to 95.4％.Additionally,WPI-ADA copolymer microcapsules exhibited good thermal stability.In vitro simulated digestion experiments demonstrated that WPI-ADA copolymer microcapsules exhibited certain controlled release capabilities,extending the time for maximum curcumin release from 12 hours to 24 hours in simulated gastric fluid and intestinal fluid.[Conclusion]Under covalent interaction,WPI-ADA copolymers can improve the physicochemical properties and curcumin release properties of microcapsules,and can be used to modify the microcapsule system and the delivery of hydrophobic active substances.[Ch,8 fig.1 tab.27 ref.]
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