The extensive use of chemical pesticides has brought about a series of problems,such as pest resistance,environmental pollution and agricultural product safety.The new sustainable plant protection strategy has become an inevitable requirement for the green development of agriculture.In recent years,the application potential of RNAi in plant disease and pest control has received more and more attention,and the research and development of biological pesticides based on RNAi(namely nucleic acid pesticides)is becoming more and more rapid.Nucleic acid pesti-cides are based on spray-induced gene silencing(SIGS).Exogenous application of dsRNA targeting target pathogens or pests can trigger RNAi to inhibit pathogens or pests and achieve specific control of target diseases and pests.Due to the advantages of target specificity,environmental friendliness and low resistance of nucleic acid pesticides,the research and development process of RNAi are accelerating.Therefore,nucleic acid pesticides are expected to be-come an important supplement or substitute for chemical pesticides.In this paper,the mechanism of action,research progress,product development and application status,risks in the process of commercialization and use,and prob-lems that need to be noted of nucleic acid pesticides are reviewed,in order to provide reference for related research.
nucleic acid pesticidesRNAidsRNAdisease and pest control
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