Hypoxia is the most common tumor microenvironment caused by rapid proliferation of tumor cells,and hypox-ia-inducible factor(HIF)is the main transcription factor for tumor cells to adapt to hypoxia.Current research has found that HIF can interact with a variety of mesenchymal cells such as fibroblasts,endothelial cells and immune cells in the tumor microenvironment,leading to the transcription and expression of target genes in response to hypoxia,which ulti-mately promotes tumor angiogenesis,and induces physiological changes such as migration,invasion,and immune escape of tumor cells.However,the signaling pathways involved in the HIF regulatory mechanism are complex,and the mecha-nism of HIF in the tumor microenvironment need to be further investigated,also most HIF inhibitors are still in the preclinical research stage.This paper reviews the research progress on the effects of HIF on tumor mesenchymal stro-mal cells to provide a theoretical basis for the diagnosis,prevention and treatment of tumors targeting HIF.
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维普
