摘要
目的 了解2011-2022年浙江省苍南县孕产妇乙型肝炎病毒(HBV)携带情况及其影响因素,为指导HBV携带者妊娠期保健提供依据.方法 以苍南县第三人民医院2011年1月-2022年7月住院分娩的34 403名孕产妇为研究对象,收集孕产妇的人口学信息、HBV携带情况和妊娠结局等临床资料.分析苍南县孕产妇HBV携带率,并采用多因素logistic回归模型分析HBV携带的影响因素.结果 收集34 403名孕产妇资料,年龄M(QR)为27.00(7.00)岁.流动人口 8 118人,占23.60％.HBV携带者 1 182例,携带率为3.44％;2011-2014年、2015-2018年和2019-2022年携带率分别为1.59％、4.08％和6.86％,呈上升趋势(P＜0.05).多因素logistic回归分析结果显示,预产年龄(20～＜25岁,OR=1.832,95％CI:1.037～3.235;25～＜30岁,OR=2.404,95％CI:1.372～4.214;30～＜35岁,OR=2.914,95％CI:1.656～5.129;35～＜40岁,OR=3.116,95％CI:1.741～5.576;≥40岁,OR=2.358,95％CI:1.145～4.858)、流动人口(OR=0.670,95％CI:0.574～0.782)、前胎剖宫产术后瘢痕子宫(OR=1.228,95％CI:1.076～1.521)、分娩年份(2015-2018年,OR=2.504,95％CI:2.143～2.926;2019-2022年,OR=4.425,95％CI:3.779～5.182)是孕产妇HBV携带的影响因素.结论 2011-2022年苍南县孕产妇HBV携带率呈上升趋势,预产年龄、流动人口、分娩年份和前胎剖宫产术后瘢痕子宫是孕产妇HBV携带的影响因素.
Abstract
Objective To investigate the prevalence of hepatitis B virus(HBV)carriage among pregnant and lying-in women in Cangnan County,Zhejiang Province from 2011 to 2022 and identify the influencing factors,so as to provide insights into the guidance of healthcare among HBV carriers during pregnancy.Methods A total of 34 403 women de-livered in The Third People's Hospital of Cangnan County from January 2011 to July 2022 were enrolled,and their de-mographics,HBV carriage and pregnant outcomes were collected.The prevalence of HBV carriage was analyzed among pregnant and lying-in women,and factors affecting HBV carriage were identified using a multivariable logistic regres-sion model.Results A total of 34 403 pregnant and lying-in women were enrolled,with a median age of 27.00(inter-quartile range,7.00)years,and including 8 118 floating populations(23.60％).The overall prevalence of HBV carriage was 3.44％,and the prevalence of HBV carriage was 1.59％from 2011 to 2014,4.08％from 2015 to 2018 and 6.86％from 2019 to 2022,appearing a tendency towards a rise(P＜0.05).Multivariable logistic regression analysis identified es-timated age of delivery(20-24 years,OR=1.832,95％CI:1.037-3.235;25-29 years,OR=2.404,95％CI:1.372-4.214;30-34 years,OR=2.914,95％CI:1.656-5.129;35-39 years,OR=3.116,95％CI:1.741-5.576;40 years and older,OR=2.358,95％CI:1.145-4.858),floating population(OR=0.670,95％CI:0.574-0.782),scarred uterus after cesarean section(OR=1.228,95％CI:1.076-1.521)and year of delivery(from 2015 to 2018,OR=2.504,95％CI:2.143-2.926;from 2019 to 2022,OR=4.425,95％CI:3.779-5.182)as factors affecting HBV carriage among pregnant and lying-in women.Con-clusions The prevalence of HBV carriage rate appeared a tendency towards a rise among pregnant and lying-in women in Cangnan County from 2011 to 2022.Estimated age of delivery,floating population,year of delivery and scarred uter-us after cesarean section are factors affecting HBV carriage.
基金项目
苍南县科技局社会科技(医卫)项目(2023S30)
万方数据