摘要
目的 了解浙江省平湖市非细菌性呼吸道感染的病原谱构成,为呼吸道传染病防控提供依据.方法 收集2021年1月—2022年11月平湖市第一人民医院就诊的发热患者咽或鼻咽拭子,采用多重实时荧光定量PCR法检测鼻病毒(RhV)、呼吸道合胞病毒(RSV)、副流感病毒(PIV)、腺病毒(ADV)、偏肺病毒(MPV)、冠状病毒(CoV)、博卡病毒(Boca)、肠道病毒(EV)、流感病毒(Flu)、肺炎衣原体(CP)和肺炎支原体(MP)核酸,分析不同年龄人群和季节各种病原体的检出率和混合感染情况.结果 收集592份标本检出至少1种病原体核酸阳性212份,总检出率为35.81％,RhV(9.80％)、PIV(7.26％)、FLu(6.76％)、RSV(4.39％)和CoV(3.72％)检出率相对较高.0～＜3岁、3～＜18岁患者检出率高于18～＜60岁患者;秋季检出率高于春季和冬季(均P<0.05).检出混合感染2种病原体23份,占3.89％,以PIV、CoV、RhV、ADV混合其他病原体检出较多.结论 2021-2022年11月平湖市非细菌性呼吸道感染病原体以RhV、PIV、FLu、RSV和CoV为主,且存在一定比例的混合感染,需针对婴幼儿和儿童加强呼吸道感染防控工作.
Abstract
Objective To understand the pathogen spectrum composition of non-bacterial respiratory infections in Ping-hu City,Zhejiang Province,so as to provide insights for the prevention and control of respiratory infectious diseases.Methods A total of 592 throat or nasopharynx swab samples were collected from fever patients in Pinghu First Peo-ple's Hospital from Jamuary 2021 to November 2022.Multiple real-time fluorescence quantitative polymerase chain reac-tion was used to detect the nucleic acids of rhinovirus(RhV),respiratory syncytial virus(RSV),parainfluenza virus(PIV),adenovirus(ADV),metapneumovirus(MPV),coronavirus(CoV),Boca virus(Boca),enterovirus(EV),influenza vi-rus(Flu),chlamydia pneumoniae(CP)and mycoplasma pneumoniae(MP).The detection rates of pathogens and mixed in-fections in different age groups and seasons were analyzed.Results A total of 212 samples were tested positive for at least one pathogen's nucleic acid from 592 samples,with a total detection rate of 35.81％.The detection rates of RhV(9.80％),PIV(7.26％),Flu(6.76％),RSV(4.39％)and CoV(3.72％)were relatively high.The detection rates were high-er among patients at ages of 0 to 2 years and 3 to 17 years than among patients at ages of 18 to 59 years,and in au-tumn than in spring and winter(all P<0.05).Twenty-three samples were infected by mixed pathogens,accounting for 3.89％.The mixed infections were all detected two pathogens,with PIV,CoV,RhV,and ADV predominant.Conclu-sions From 2021 to November 2022,the main pathogens of non-bacterial respiratory infections in Pinghu City were RhV,PIV,FLu,RSV and CoV,and there were mixed infections.It is necessary to strengthen the prevention and con-trol of respiratory infection in infants and children.
维普
万方数据