嘉兴市13价肺炎球菌多糖结合疫苗疑似预防接种异常反应监测结果
Surveillance of adverse event following immunization with 13-valent pneumococcal polysaccharide conjugate vaccine in Jiaxing City
许荣全 1杜哲群 1余鹏飞 1沈国初 1胡洁 1张阳春1
作者信息
- 1. 嘉兴市疾病预防控制中心免疫规划科,浙江 嘉兴 314050
- 折叠
摘要
目的 了解浙江省嘉兴市13价肺炎球菌多糖结合疫苗(PCV13)疑似预防接种异常反应(AEFI)发生情况,为PCV13安全性监测与评价提供依据.方法 通过中国疾病预防控制信息系统国家免疫规划信息系统AEFI监测模块收集2020-2022年嘉兴市PCV13 AEFI监测资料,包括人口学信息、接种时间、AEFI发生时间和临床表现等;描述性分析AEFI报告发生率、人群分布、地区分布和临床症状等.结果 2020-2022年嘉兴市报告PCV13 AEFI 455例,报告发生率为232.33/10万剂;一般反应、异常反应和偶合症分别报告431、21和3例,报告发生率分别为220.07/10万剂、10.72/10万剂和1.53/10万剂,无心因性反应、疫苗质量事故和接种事故报告.AEFI病例中,男童258例,女童197例,男女性别比为1.31∶1;年龄以<1岁为主,288例占63.30%;海宁市报告例数最多,87例占19.12%.接种后<24 h报告AEFI 349例,占76.70%.临床症状以红肿、发热和硬结为主,分别为260、214和109例,报告发生率分别为132.76/10万剂、109.27/10万剂和55.66/10万剂.455例AEFI病例中,450例治愈,5例好转.结论 2020-2022年嘉兴市PCV13 AEFI以一般反应为主,症状较轻,大多数发生在24h内,预后良好.
Abstract
Objective To investigate the incidence of adverse event following immunization(AEFI)with 13-valent pneu-mococcal polysaccharide conjugate vaccine(PCV13)in Jiaxing City,Zhejiang Province,so as to provide insights into safety monitoring and evaluation of PCV13.Methods Surveillance data of AEFI with PCV13 in Jiaxing City from 2020 to 2022 were collected from the AEFI Monitoring Information Management System of the Immunization Planning System of Chinese Disease Prevention and Control Information System,including demographic information,vaccination time,time of AEFI occurrence and clinical symptoms,and the reported incidence,population and district distribution,and clinical symptoms of AEFI with PCV13 were descriptively analyzed.Results Totally 455 cases of AEFI with PCV13 were re-ported in Jiaxing City from 2020 to 2022,with a reported incidence rate of 232.33/105 doses.There were 431,21 and 3 cases of general,abnormal,coincidence and psychogenic reactions,with reported incidence rates of 220.07/105 doses,10.72/105 doses and 1.53/105 doses,respectively,and no reports of causal reaction,vaccine quality accident and vaccina-tion accident.The AEFI cases included 258 boys and 197 girls,with a boy/girl ratio of 1.31∶1,and 288 children at ages of less than a year(63.30%).The largest number of AEFI was reported in Haining City(87 cases,19.12%),and there were 349 AEFI cases(76.70%)within 24 hours following vaccination.The clinical symptoms mainly included red-ness and swelling,fever and induration,with reported incidence rates of 132.76/105 doses(260 cases),109.27/105 doses(214 cases),and 55.66/105 doses(109 cases),respectively.There were 450 cases cured and 5 cases improved in 455 cases of AEFI.Conclusions General reaction is the predominant AEFI in Jiaxing City from 2020 to 2022,with mild symptoms.Most AEFI occurs within 24 hours following vaccination,and has a good prognosis.
关键词
13价肺炎球菌多糖结合疫苗/疑似预防接种异常反应/监测Key words
13-valent pneumococcal polysaccharide conjugate vaccine/suspected adverse event following immunization/surveillance引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据