Objective To explore incidence trend of hepatitis C in Chifeng City,Inner Mongolia Autonomous Region from 2008 to 2022,so as to provide the basis for formulating prevention and control measures for hepatitis C.Methods Data of reported hepatitis C cases in Chifeng City from 2008 to 2022 was collected through the Infectious Disease Infor-mation Reporting Management System.Trends in incidence of hepatitis C were analyzed using annual percent change(APC)and average annual percent change(AAPC).Impact of age,period and birth cohort on the risk of developing hep-atitis C were analyzed by an age-period-cohort model.Results The annual average reported incidence rate of hepatitis C in Chifeng City was 59.13/105 from 2008 to 2022.The incidence showed an upward trend from 2008 to 2018(APC=9.405%,P<0.05)and a downward trend from 2018 to 2022(APC=-17.475%,P<0.05),but the overall trend was not statistically significant(AAPC=0.937%,P>0.05).The age-period-cohort model analysis showed that the incidence risks of hepatitis C in the residents aged 0 to 4 years and 45 to 84 years were higher than those in the residents aged 40 to 44 years(the control group).The incidence risk of hepatitis C increased with age from 40 to 79 years.Compared with 2008-2012,the incidence risk of hepatitis C showed an increasing trend followed by a decline in 2008-2022.The incidence risk was higher in 2013-2017 and lower in 2018-2022 than in 2008-2012.The incidence risk of hepatitis C showed an increasing trend followed by a decreasing trend by using the birth cohort from 1968 to 1972 as the control.The birth cohort from 1953 to 1977 had a higher incidence risk of hepatitis C than other birth cohorts.Conclusions The overall incidence of hepatitis C in Chifeng City from 2008 to 2022 appeared a tendency towards a decline,and the incidence risk increased with age.Screening and health education for the elderly and high-risk birth cohorts should be strengthened.