Objective To investigate the trends in incidence and epidemiological characteristics of notifiable infectious diseases in Huzhou City,Zhejiang Province from 2005 to 2023,so as to provide insights into optimizing infectious dis-ease surveillance and control.Methods Data of notifiable infectious disease cases in Huzhou City from 2005 to 2023 were collected from the Infectious Disease Report Information System of Chinese Disease Prevention and Control Informa-tion System.Trends in incidence were analyzed using annual percent change(APC)and average annual percent change(AAPC).The population distribution and seasonal characteristics were descriptively analyzed.Results From 2005 to 2023,a total of 504 283 cases of notifiable infectious diseases were reported in Huzhou City,with an annual crude in-cidence rate of 892.65/105 and a standardized incidence rate of 989.21/105.The incidence rate of notifiable infectious diseases in Huzhou City showed an upward trend(AAPC=8.886%,P<0.05),of which there was an obvious upward trend from 2021 to 2023(APC=95.996%,P<0.05).After the removal of COVID-19 incidence,the incidence trend was basically unchanged(AAPC=7.970%,P<0.05).From 2005 to 2023,the incidence rate of class A and B notifiable infec-tious diseases showed no obvious trend(P>0.05),and the incidence rate of class A and B respiratory infectious diseas-es showed an upward trend(AAPC=6.958%,P<0.05).After the removal of COVID-19 incidence,the two showed a downward trend(AAPC=-7.680%and-8.660%,both P<0.05).The incidence rate of class A and class B intestinal in-fectious diseases,blood-borne and sexually transmitted infectious diseases showed a downward trend(AAPC=-14.849%and-5.977%,both P<0.05),while the incidence rates of natural and insect-borne infectious diseases did not show a significant trend(P>0.05).The overall incidence rate of class C infectious diseases showed an upward trend(AAPC=13.058%,P<0.05).The incidence rate ratio(IRR)of notifiable infectious diseases between males and females was 1.26(95%CI:1.25-1.27).A total of 204 043 cases under 10 years were reported,accounting for 40.46%.The peak incidence of class A and B respiratory infectious diseases was in January,May and June,while that of class A and B intestinal in-fectious diseases was from June to October.The peak incidence of class C respiratory infectious diseases was in January,March,April and December,while that of class C intestinal infectious diseases was from May to August and from No-vember to December.Conclusions The incidence rate of notifiable infectious diseases in Huzhou City showed an up-ward trend from 2005 to 2023,which was more obvious from 2021 to 2023.Men and children under 10 years were the high-risk population.The incidence of respiratory and intestinal infectious diseases had obvious seasonal characteristics.
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