Association between leukocyte telomere length and cataracts:a bidirectional Mendelian randomization study
Objective To examine the association between leukocyte telomere length and cataract using bidirectional Men-delian randomization(MR)approach,so as to provide the basis for early diagnosis and prevention of cataracts.Methods Leukocyte telomere length data were collected through a meta analysis of genome-wide association studies(GWAS),in-cluding 78 952 participants,and the GWAS data of cataract were collected through the UK Biobank,including 8 890 cases and 454 120 controls.A bidirectional MR analysis was performed using the inverse-variance weighted(IVW)method,and single nucleotide polymorphisms(SNPs)which were associated with leukocyte telomere length were selected as instrumental variables.The heterogeneity was assessed using the Cochran's Q test,the horizontal pleiotropy was as-sessed using the MR-Egger regression and the outlier was verified with the leave-one-out and MR-PRESSO test.Re-sults Forward MR analysis results showed that shortened leukocyte telomere length had an increased risk of cataract(OR=0.991,95%CI:0.990-0.997).Reverse MR analysis results showed no statistically significant association between leu-kocyte telomere length and cataract(P>0.05).Cochran's Q test detected no heterogeneity,and neither the MR-Egger re-gression nor the MR-PRESSO test revealed horizontal pleiotropy of instrumental variables(both P>0.05).Leave-one-out analysis showed robustness of the MR analysis results.Conclusion Shorter leukocyte telomere length might be associat-ed with increased risk of cataract.
telomere lengthcataractMendelian randomizationgenome-wide association study
NETL
NSTL
万方数据
