MAGI2-AS3在肿瘤发生发展中的调控机制研究进展
Regulatory function of long noncoding RNA MAGI2-AS3 in tumor development:a review
顾思萌 1李雅晖 2王晓峰 3莫哲1
作者信息
- 1. 浙江省疾病预防控制中心环境与健康所,浙江 杭州 310051
- 2. 杭州医学院,浙江 杭州 310012
- 3. 浙江省疾病预防控制中心,浙江 杭州 310051
- 折叠
摘要
长链非编码RNA(lncRNA)与肿瘤的发病机制密切相关,是近年来肿瘤病因学研究的热门领域.MAGI2-AS3作为肿瘤相关lncRNA,可从表观遗传学、转录及转录后调控等多层面发挥作用,参与肿瘤发生发展的多个阶段,对于肿瘤诊断、治疗和预后具有潜在应用价值.本文主要就MAGI2-AS3在常见恶性肿瘤中的表达、调控机制及临床应用价值进行综述,为肿瘤防治提供参考.
Abstract
Long noncoding RNA(lncRNA)is closely related to the pathogenesis of cancer,representing a burgeoning field in tumor research in recent years.MAGI2-AS3,a tumor-associated lncRNA,exerts pivotal roles in epigenetics,transcrip-tion and post-transcriptional regulation.Studies have suggested that MAGI2-AS3 may be involved in multiple stages of tumor development,and has potential applications for tumor diagnosis,therapy and prognosis.This review summarizes the expression,regulatory mechanism and clinical application value of MAGI2-AS3 in common malignant tumrs,provid-ing the reference for tumor prevention and treatment.
关键词
MAGI2-AS3/肿瘤/长链非编码RNA/表观遗传学Key words
MAGI2-AS3/tumor/long noncoding RNA/epigenetics引用本文复制引用
基金项目
浙江省自然科学基金项目(LQ22H260003)
出版年
2024
NETL
NSTL
万方数据