Long noncoding RNA(lncRNA)is closely related to the pathogenesis of cancer,representing a burgeoning field in tumor research in recent years.MAGI2-AS3,a tumor-associated lncRNA,exerts pivotal roles in epigenetics,transcrip-tion and post-transcriptional regulation.Studies have suggested that MAGI2-AS3 may be involved in multiple stages of tumor development,and has potential applications for tumor diagnosis,therapy and prognosis.This review summarizes the expression,regulatory mechanism and clinical application value of MAGI2-AS3 in common malignant tumrs,provid-ing the reference for tumor prevention and treatment.