Objective To examine the association between serum vitamin D level and thyroid function indicators among elderly patients with type 2 diabetes mellitus(T2DM),so as to provide the evidence for the prevention and treatment of thyroid function abnormality among elderly patients with T2DM.Methods Inpatients aged 60 years and older and ad-mitted to the department of endocrinology of Zhejiang Hospital were selected as the study subjects.Gender,age,course of disease and other basic information were collected through questionnaire surveys.The serum 25-hydroxyvitamin D[25-(OH)D],thyroid stimulating hormone(TSH),free triiodothyronine(FT3),free thyroxine(FT4),total triiodothyronine(TT3),and total thyroxine(TT4)were measured.The correlation between serum vitamin D level and thyroid function in-dicators in elderly patients with T2DM was evaluated by a multiple linear regression model.Results A total of 402 el-derly patients with T2DM were surveyed,including 210 males(52.24%)and 192 females(47.76%),and had a median age of 70.00(interquartile range,12.00)years and a median course of disease of 14.00(interquartile range,14.00)years.There were 162 patients with insufficiency of vitamin D(40.30%)and 182 patients with deficiency(45.27%).The levels of TSH and glycated hemoglobin in the vitamin D deficiency group were(2.34±1.66)μIU/mL and(8.83±2.14)%,respectively,which were higher than those in the normal group[(1.74±1.10)μIU/mL and(8.11±1.75)%;P<0.05].The levels of FT3 and FT3/FT4 in the vitamin D deficiency group were(2.86±0.48)μIU/mL and 2.85±0.71,respectively,which were lower than those in the vitamin D insufficiency group[(3.09±0.47)pg/mL and 3.14±0.81,P<0.05].Multiple linear regression analysis showed a negative correlation between 25-(OH)D and TSH(β'=-0.159,P=0.001).Conclu-sion The vitamin D deficiency may be associated with the increase of TSH level among the elderly patients with T2DM.
type 2 diabetes mellitusvitamin Dthyroid function indicatorthe elderly
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