Objective To analyze the disease burden of acute gastrointestinal illness(AGI)caused by non-typhoidal Sal-monella and Vibrio Parahaemolyticus in Zhejiang Province,so as to provide the reference for the prevention and control of foodborne diseases.Methods The detection rates of non-typhoidal Salmonella and Vibrio parahaemolyticus in 2022 were collected through the Zhejiang Foodborne Disease Outbreak Surveillance System.The number of cases,incidence and hospitalizations of AGI caused by non-typhoidal Salmonella and Vibrio parahaemolyticus were calculated.Disability-adjusted life years(DALY)were used to analyze the disease burden of AGI caused by non-typhoidal Salmonella and Vibrio parahaemolyticus among different age groups.Results The number of AGI cases caused by non-typhoidal Salmo-nella in Zhejiang Province in 2022 was 889 500 person-times,the incidence rate was 1 352.42/105,the number of hos-pital visits was 328 900 person-times,the DALY was 972.69(95%CI:771.68-1 164.16)person-years,and the DALY rate was 1.48(95%CI:1.17-1.77)/105.The incidence rate and DALY rate were highest in the children aged under 5 years,reaching 3 989.51/105 and 13.93(95%CI:8.67-18.42)/105,respectively.The number of AGI cases caused by Vibrio parahaemolyticus in Zhejiang Province was 639 400 person-times,the incidence rate of 972.16/105,the number of hospital visits was 166 800 person-times,the DALY was 509.30(95%CI:411.75-699.62)person-years,and the DALY rate was 0.78(95%CI:0.63-1.06)/105.The incidence rate and DALY rate were highest in the residents aged 45 to<65 years,reaching 1 383.55/105 and 1.27(95%CI:1.14-1.96)/105,respectively.Conclusions The incidence and DALY of AGI caused by non-typhoidal Salmonella were relatively high in Zhejiang Province.The AGI caused by non-typhoi-dal Salmonella in the children under 5 years and the AGI caused by Vibrio parahaemolyticus in the residents aged 45 to<65 years need to be monitored with priority.