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钒及其化合物毒性作用研究进展

Research progress on toxic effects of vanadium and its compounds

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钒因其可塑性、可锻性良好而广泛应用于钢铁制造、航空航天和医疗等行业,但大量钒化合物被排放到环境中,人类主要通过环境和职业暴露于钒.钒及其化合物可导致生殖系统、呼吸系统、神经系统和免疫系统等多系统损伤,其毒性作用机制可能与氧化应激、表观遗传损伤、DNA损伤、细胞凋亡及细胞增殖失调有关.本文对钒暴露导致的健康危害及其作用机制进行综述,为钒及其化合物的毒性作用研究提供参考.
Vanadium is widely used in the steel manufacturing,aerospace and medical industries because of its good plasticity and malleability,and is released into the environment in large quantities.Human were exposed mainly through environmental and occupational exposure.Vanadium and its compounds can cause multi-system damage to the reproduc-tive,respiratory,neurological,and immune systems,and the toxic mechanisms may be related to oxidative stress,epigen-etic damage,DNA damage and repair,apoptosis,and dysregulation of cell proliferation.This article summarizes the health hazards caused by vanadium exposure and its mechanism,providing the reference for the studies into the toxic effects of vanadium and its compounds.

vanadiumtoxic effectoxidative stressDNA damagemechanism

李佳萍、蒋兆强、李涛

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杭州医学院公共卫生学院,浙江 杭州 310013

毒性作用 氧化应激 DNA损伤 机制

浙江省基础公益研究计划项目浙江省医药卫生科技计划项目浙江省一流学科(A类)公共卫生与预防医学

LTGY23H2600082023KY654

2024

预防医学
浙江省预防医学会

预防医学

CSTPCD
影响因子:1.002
ISSN:2096-5087
年,卷(期):2024.36(9)