Objective To investigate the prevalence of depressive symptoms among college freshmen and analyze their in-fluencing factors,so as to provide insights into the prevention and intervention of depressive symptoms among college students.Methods The freshmen enrolled in a college of Hunan Province from 2020 to 2022 were recruited,and demo-graphic data,diet and sleep status were collected using questionnaire surveys.Depressive symptoms were evaluated us-ing Patient Health Questionnaire-9.Factors affecting depressive symptoms were analyzed using a multivariable logistic re-gression model.Results Totally 17 862 questionnaires were allocated,and 16 480 valid questionnaires were recovered,with an effective rate of 92.26%.There were 3 374 students of 2020 cohort,7 038 students of 2021 cohort and 6 068 students of 2022 cohort,6 029 boys(36.58%)and 10 451 girls(63.42%).The prevalence of depressive symptoms among freshmen was 41.37%.Multivariable logistic regression analysis showed that female(OR=1.482,95%CI:1.377-1.594),enrolling through the college entrance examination(OR=1.561,95%CI:1.384-1.809),depression history(OR=1.990,95%CI:1.513-2.618),abnormal marital status of parents(divorced,OR=1.197,95%CI:1.064-1.348;other prob-lem,OR=1.401,95%CI:1.174-1.672),abnormal diet(mild,OR=2.883,95%CI:2.585-3.105;moderate,OR=6.755,95%CI:4.653-9.808;severe,OR=38.897,95%CI:12.200-124.012)and abnormal sleep(mild,OR=2.785,95%CI:2.593-2.992;moderate,OR=9.009,95%CI:7.011-11.578;severe,OR=29.281,95%CI:14.163-60.536)were associated with in-creased risk of depressive symptoms among college freshmen.Conclusion The prevalence of depressive symptoms among college freshmen is relatively high,and is influenced by gender,mode of admission,history of depression,paren-tal marital status,diet and sleep.