摘要
阿尔茨海默病(AD)是以认知功能障碍和行为损害为特征的进行性神经退行性疾病,目前主要依靠药物治疗,但效果有限且伴随不良反应.多模式非药物干预(MNPI)是将2种或以上的非药物干预方式结合,协同改善AD患者的认知功能、精神行为症状、日常生活能力和生活质量,具有安全、经济和简便等优点.本文收集2018—2024年国内外发表的MNPI相关文献,对认知训练、体力活动联合其他干预方式的MNPI应用进行综述,为制定个性化AD干预方案提供参考.
Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive dysfunction and behavioral impairments.Currently,the treatment mainly relies on pharmacotherapy,yet its effectiveness is limited and accompanied by adverse reactions.Multimodal non-pharmacological interventions (MNPI),which combine two or more non-pharmacological intervention approaches,can synergistically improve cognitive function,neuropsychiatric symp-toms,activities of daily living,and quality of life in AD patients,and offers advantages of safety,cost-effectiveness and simplicity.This article reviews MNPI-related literature published domestically and internationally from 2018 to 2024,and focuses on the application of cognitive training,physical activity,and other combined intervention methods in MN-PI,providing the reference for developing personalized interventions for AD.
维普
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