Association between sleep and frailty:a Mendelian randomization study
Objective To examine the association between sleep and frailty using the bidirectional two-sample Mende-lian randomization (MR) approach,so as to provide the basis for the prevention and intervention of frailty.Methods The data on single nucleotide polymorphisms (SNP) related to sleep duration,insomnia and morning chronotype were col-lected from genome-wide association studies (GWAS) and meta-analysis of GWAS,involving 446118,1331010 and 697828 participants,respectively.The frailty was evaluated using the frailty index,and the relevant SNP data were col-lected from a meta-analysis of GWAS involving 175226 participants.A bidirectional MR analysis was performed using the inverse-variance weighted method.Sensitivity analyses employed the weighted median method,the maximum likeli-hood-based method,the MR-Egger regression,and the MR-PRESSO test.Results Forward MR analysis showed that longer sleep duration (β=-0.170,95％CI:-0.255 to-0.085) and morning chronotype (β=-0.036,95％CI:-0.058 to-0.014) decreased the risk of frailty,while insomnia increased the risk of frailty (β=0.167,95％CI:0.149-0.184).Re-verse MR analysis showed that frailty increased the risk of insomnia (OR=1.645,95％CI:1.278-2.117).Both bidirection-al MR results were robust,which excluded the impact of heterogeneity and horizontal pleiotropy.Conclusion Sleep du-ration,insomnia,and morning chronotype are associated with frailty.
万方数据
维普
