Casual Association Between Coffee Intake and Prostate Cancer Based on Two-sample Mendel Randomization
Objective To assess the causal relationship between coffee intake and prostate cancer risk by using the two-sample Mendel randomization(MR)method.Methods The genome-wide association study(GWAS)data on coffee intake(exposure)and prostate cancer(outcome)were obtained from two independent data sets in UK Biobank.The inverse variance weighted method(IVW),weighted median estimator method(WME),and MR-Egger method were used for MR analyses.The OR value and 95％CI were used to represent the association between coffee intake and prostate cancer.In addition,the MR-Egger method was performed for pleiotropic and heterogeneity tests,and the leave-one-out method was used for sensitivity analysis.Results A total of 38 SNP were selected as instrumental variables.The IVW method showed that coffee intake might reduce the risk of prostate cancer(OR=0.994;95％CI:0.990-0.999;P=0.009).The WME method obtained the same conclusions(OR=0.991;95％CI:0.985-0.999;P=0.018),but MR-Egger regression did not find a causal relationship between coffee intake and prostate cancer(OR=0.992;95％CI:0.983-1.000;P=0.084).The MR-Egger method showed no pleiotropy(intercept=4.2E-5;P=0.581)or heterogeneity(Q=27.20;P=0.854)among the instrumental variables.The sensitivity analysis indicated that the conclusion was robust.Conclusion Two-sample Mendel randomization analysis reveals that coffee consumption might reduce the risk of prostate cancer.
万方数据
维普
