Progress of Microsatellite(GT/CA)n Repeat Polymorphisms in Non-small Cell Lung Cancer
Non-small cell lung cancer(NSCLC)is the most important histological type of lung cancer.This disease affects a large number of patients,and the prognosis of advanced patients is poor.Although great progress has been achieved for existing treatment methods,challenges still exist.Cancer is a genetic disease,and its occurrence is accompanied by substantial genomic-sequence instability.(GT/CA)n repeat sequence is a common microsatellite sequence serving as transcriptional function-related regions,DNA-methylation modification sites,and other functional sites.Its polymorphism is closely related to the expression of EGFR,HO-1,and HIF-1α in NSCLC patients.(GT/CA)n repeat sequence is the breakthrough point to explore the molecular mechanism of NSCLC occurrence and development,develop molecular markers for diagnosis and prognosis and epigenetics research.This paper summarizes the studies on(GT/CA)n repeat polymorphisms in NSCLC with the aim of providing references for relevant NSCLC research.
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