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靶向T细胞免疫治疗急性髓性白血病的策略

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急性髓性白血病(AML)常伴有T细胞免疫功能不全,由于免疫检查点(IC)分子表达上调引起T细胞耗竭是其重要原因之一.利用IC抑制剂治疗AML有一定的临床效果,但患者T细胞耗竭的异质性很大,且还存在其他原因引起的T细胞免疫功能不全,多层面分析区分不同类型的免疫缺陷而采取相应的靶向T细胞免疫治疗才是理想的策略.
Strategy of Targeted T Cell Immunotherapy for Acute Myeloid Leukemia
T cell dysfunction is a common feature in patients with acute myeloid leukemia(AML).The up-regulation of immune checkpoint(IC)proteins resulting in T cell exhaustion is a key reason for T cell dysfunction.Immunotherapy with IC inhibitors exerts a remarkable effect on AML.However,due to the heterogeneity of T cell exhaustion and other factors that impair T cell function in patients with AML,the optimization of targeted T cell immunotherapy strategy for AML might be based on the multidimensional investigation of immune deficiency with different T cell subtypes.

Acute myeloid leukemiaT cellExhaustionImmune checkpoint proteinImmunotherapy

李扬秋

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510632 广州,暨南大学基础医学与公共卫生学院血液学研究所、再生医学教育部重点实验室

急性髓性白血病 T细胞 耗竭 免疫检查点分子 免疫治疗

国家自然科学基金国家自然科学基金

8229363082070152

2024

肿瘤防治研究
湖北省卫生厅,中国抗癌协会,湖北省肿瘤医院

肿瘤防治研究

CSTPCD
影响因子:0.737
ISSN:1000-8578
年,卷(期):2024.51(4)
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