靶向T细胞免疫治疗急性髓性白血病的策略
Strategy of Targeted T Cell Immunotherapy for Acute Myeloid Leukemia
李扬秋1
作者信息
- 1. 510632 广州,暨南大学基础医学与公共卫生学院血液学研究所、再生医学教育部重点实验室
- 折叠
摘要
急性髓性白血病(AML)常伴有T细胞免疫功能不全,由于免疫检查点(IC)分子表达上调引起T细胞耗竭是其重要原因之一.利用IC抑制剂治疗AML有一定的临床效果,但患者T细胞耗竭的异质性很大,且还存在其他原因引起的T细胞免疫功能不全,多层面分析区分不同类型的免疫缺陷而采取相应的靶向T细胞免疫治疗才是理想的策略.
Abstract
T cell dysfunction is a common feature in patients with acute myeloid leukemia(AML).The up-regulation of immune checkpoint(IC)proteins resulting in T cell exhaustion is a key reason for T cell dysfunction.Immunotherapy with IC inhibitors exerts a remarkable effect on AML.However,due to the heterogeneity of T cell exhaustion and other factors that impair T cell function in patients with AML,the optimization of targeted T cell immunotherapy strategy for AML might be based on the multidimensional investigation of immune deficiency with different T cell subtypes.
关键词
急性髓性白血病/T细胞/耗竭/免疫检查点分子/免疫治疗Key words
Acute myeloid leukemia/T cell/Exhaustion/Immune checkpoint protein/Immunotherapy引用本文复制引用
基金项目
国家自然科学基金(82293630)
国家自然科学基金(82070152)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据