摘要
肺癌具有高发生率、高侵袭性和高致亡率的特点,其发生发展受多方面因素影响.线粒体作为普遍存在于人体内的细胞器,通过调节细胞代谢、信号转导、氧化应激和基因组不稳定性等过程,影响肺癌的发生和发展.本文总结近年来有关线粒体靶向药物、线粒体转移和线粒体基因疗法等治疗肺癌的研究进展,探讨线粒体治疗肺癌的原理和前景,以期为肺癌的治疗提供新的思路.
Abstract
Lung cancer is characterized by high incidence and mortality rates and invasiveness,and its occurrence and development are influenced by various factors.Mitochondria,as ubiquitous organelles in the human body,regulate cellular processes,such as metabolism,signal transduction,oxidative stress,and genomic instability,thereby affecting the initiation and progression of lung cancer.This article summarizes the recent research progress on mitochondrial-targeted drugs,mitochondrial transfer,and mitochondrial gene therapy for lung cancer treatment.This work also discusses the principles and prospects of mitochondrial therapy to provide new insights for lung cancer treatment.
国家科技期刊平台
NSTL
维普
万方数据