晚期非小细胞肺癌免疫治疗:研究进展和展望
Immunotherapy for Advanced Non-small Cell Lung Cancer:Research Progress and Perspectives
王婧怡 1钟雨玲 2邬麟1
作者信息
- 1. 410013 长沙,湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院胸内二科
- 2. 421001 衡阳,南华大学衡阳医学院,湖南省肿瘤医院研究生协作培养基地
- 折叠
摘要
免疫治疗已经改变了晚期非小细胞肺癌(NSCLC)的治疗格局,在一线及后线治疗中均显现出巨大潜能.同时,随着免疫治疗的广泛应用,仍有许多问题需要进一步探讨,如疗效预测生物标志物的探索、免疫治疗模式的优化、免疫相关不良反应和特殊人群的管理等.本综述梳理了晚期NSCLC免疫治疗的研究进展,并探讨了面临的挑战和未来发展方向.
Abstract
Immunotherapy has changed the treatment landscape of advanced non-small cell lung cancer(NSCLC),showing great potential in the treatment of untreated and relapsed or refractory(R/R)patients.However,numerous issues that need further exploration remain with the wide application of immunotherapy.They include the exploration of biomarkers for efficacy prediction,the optimization of immunotherapy modalities,immune-related adverse effects,and the management of special populations.This review summarizes the progress of the research on immunotherapy for advanced NSCLC and discusses its challenges and future directions.
关键词
非小细胞肺癌/免疫治疗/免疫检查点抑制剂Key words
Non-small cell lung cancer/Immunotherapy/Immune checkpoint inhibitors引用本文复制引用
基金项目
湖南省科技创新项目(2023SK4024)
湖南省科技创新项目(2021SK51121)
湖南省肿瘤医院科研攀登计划(2X2020005-5)
北京市希思科临床肿瘤学研究基金会项目(Y-2019Genecast-024)
出版年
2024