细胞核遗传物质损伤后癌细胞最终命运走向分析
Final Fate of Cancer Cells After Nuclear Genetic Material Damage
王磊 1许小敏 2王建 3牟方政 4魏大荣4
作者信息
- 1. 404000 重庆,重庆大学附属三峡医院中医诊疗中心;100091 北京,中国中医科学院西苑医院肿瘤诊疗中心
- 2. 734000 张掖,河西学院医学院
- 3. 404500 重庆,重庆市云阳县中医院肿瘤科
- 4. 404000 重庆,重庆大学附属三峡医院中医诊疗中心
- 折叠
摘要
癌细胞是一类分裂增殖能力强大的恶性细胞,癌细胞依靠大量消耗人体营养来维持自身分裂增殖所需的能量.癌细胞的分裂增殖离不开细胞核内遗传物质的合成与复制,阻断或者破坏癌细胞遗传物质的合成是大部分抗肿瘤药物的作用机制之一.细胞核遗传物质作为主导细胞分裂、增殖、死亡等过程的关键物质,对细胞最终的命运走向具有决定性作用.细胞核遗传物质主要是指位于细胞核中染色质上的脱氧核糖核酸,癌细胞遗传物质损伤后其最终的命运走向如何,值得研究和分析.因此本文选择细胞周期阻滞、细胞凋亡、细胞自噬、细胞衰老等方面对癌细胞遗传物质损伤后细胞最终的命运走向进行粗略论述及分析,以期为抗肿瘤药物的机制研究提供思路.
Abstract
Cancer cells refer to a group of malignant cells with strong division and proliferation abilities.Cancer cells rely on the unstable plunder of human nutrition to sustain the large amount of energy that they need for their own division and proliferation.The division and proliferation of cancer cells are linked to the synthesis and replication of genetic material in the nucleus.Blockage or destruction of the synthesis of genetic material in cancer cells is one of the mechanisms underlying the action of most antitumor drugs.As the key material that dominates cell division,proliferation,and death,nuclear genetic material which mainly refers to the deoxyribonucleic acid located on the chromatin in the nucleus,plays a decisive role in the final fate of cells.The final fate of cancer cells after the damage of the genetic material is worthy of investigation and analysis.In this paper,we discuss and analyze the fate of cancer cells after genetic material damage from the aspect of cellular cycle arrest,apoptosis,autophagy,and senescence to provide ideas for the mechanism research on antitumor drugs.
关键词
遗传物质损伤/癌细胞/周期阻滞/凋亡/自噬/衰老Key words
Genetic material damage/Cancer cell/Cycle arrest/Apoptosis/Autophagy/Senescence引用本文复制引用
基金项目
骆常义全国名老中医专家传承工作室建设项目(中国中医药专业技术人员师承教育管理办法函[2019]41号)
重庆市科卫联合中医药科研项目(2024ZYQN014)
出版年
2024
国家科技期刊平台
NSTL
万方数据