首页|瘤胃球菌与结直肠癌的关系及其影响胃肠道的机制探讨

瘤胃球菌与结直肠癌的关系及其影响胃肠道的机制探讨

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近年研究发现,肠道菌群参与了结直肠癌的发生和发展全过程,其中瘤胃球菌属在结直肠癌患者中丰度降低,且瘤胃球菌属可以通过交叉喂养、促丁酸盐生成等途径来影响胃肠道健康.虽然现阶段对于瘤胃球菌的研究正在逐步增加,但就瘤胃球菌属对于结直肠癌发生发展的影响,仍未有统一的认识,基于此,现就瘤胃球菌属与结直肠癌的关系和可能存在的抑癌机制作一概述,为未来深入探究结直肠癌生物预防及治疗提供理论依据.
Relationship Between Ruminococcus and Colorectal Cancer and Its Anti-Cancer Mechanism
Recent studies found that the intestinal flora is involved in the occurrence and development of CRC.In particular,Ruminococcus shows a decreased abundance in patients with CRC and can affect gastrointestinal health through cross-feeding and promoting butyrate production.Although the research on Ruminococcus is gradually increasing,no unified understanding of its influence on the occurrence and development of CRC has been established.This work summarizes the relationship of Ruminococcus with CRC and its possible anticancer mechanism to provide a theoretical basis for the further exploration of biological prevention and treatment of CRC in the future.

Colorectal cancerIntestinal floraRuminococcusR.bromiiR.callidusButyrate

蔡志阳、金黑鹰、张春霞、舒磊、刘曜安

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210017 南京,南京中医药大学第二附属医院(江苏省第二中医院)肛肠外科

结直肠癌 肠道菌群 瘤胃球菌属 布氏瘤胃球菌 伶俐瘤胃球菌 丁酸盐

江苏省科技项目江苏省中医药科技发展计划

BE2023786MS2023047

2024

肿瘤防治研究
湖北省卫生厅,中国抗癌协会,湖北省肿瘤医院

肿瘤防治研究

CSTPCD
影响因子:0.737
ISSN:1000-8578
年,卷(期):2024.51(9)